GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs965513 | 1 | rs10983761 | chr9:100553957 | TSTD2 | chr9:100362364-100395962:- | -0.1 | -3.55 | 0.000404 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs755109 | 1 | rs10984361 | chr9:100681490 | C9orf156 | chr9:100666772-100684852:- | -0.17 | -4.82 | 1.68E-6 | Quantitative traits |
| BRCA | cis | rs755109 | 1 | rs10984506 | chr9:100716140 | C9orf156 | chr9:100666772-100684852:- | -0.15 | -4.09 | 4.7E-5 | Quantitative traits |
| BRCA | cis | rs7849270 | 1 | rs10988214 | chr9:131883752 | NUP188 | chr9:131703724-131769374:+ | -0.12 | -3.47 | 0.000542 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10988214 | chr9:131883752 | SH3GLB2 | chr9:131770314-131790579:- | -0.13 | -4.86 | 1.35E-6 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10988223 | chr9:131903021 | SH3GLB2 | chr9:131770314-131790579:- | -0.11 | -4.09 | 4.69E-5 | Blood metabolite ratios |
| BRCA | cis | rs10991437 | 1 | rs10991437 | chr9:107735920 | TMEM38B | chr9:108456825-108537444:+ | 0.24 | 4.07 | 5.12E-5 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs2212361 | 1 | rs11020847 | chr11:94323912 | FUT4 | chr11:94277017-94283062:+ | 0.11 | 3.5 | 0.000481 | Attention deficit hyperactivity disorder symptoms (interaction) |
| BRCA | cis | rs2212361 | 1 | rs11020847 | chr11:94323912 | MRE11A | chr11:94150469-94227040:- | 0.14 | 4.12 | 4.16E-5 | Attention deficit hyperactivity disorder symptoms (interaction) |
| BRCA | cis | rs12277962 | 1 | rs11024349 | chr11:17656148 | PIK3C2A | chr11:17099277-17229530:- | 0.11 | 3.52 | 0.000448 | Night sleep phenotypes |
| BRCA | cis | rs11026412 | 1 | rs11026412 | chr11:22114093 | ANO5 | chr11:22214722-22304913:+ | 0.24 | 5.09 | 4.15E-7 | Parkinson's disease |
| BRCA | cis | rs11026412 | 1 | rs11026416 | chr11:22125058 | ANO5 | chr11:22214722-22304913:+ | 0.27 | 5.53 | 4.05E-8 | Parkinson's disease |
| BRCA | cis | rs10160456 | 1 | rs11029915 | chr11:27311468 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.13 | 3.88E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs11029932 | chr11:27328254 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.15 | 3.57E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs7927771 | 1 | rs11039255 | chr11:47495746 | C1QTNF4 | chr11:47611216-47615961:- | -0.11 | -3.51 | 0.000461 | Subjective well-being |